In the present study, we demonstrated that sja-miR-7-5p is present in hepatocytes during the S. japonicum infection and the sja-miR-7-5p exerts anticancer effects on multiple hepatoma cells (assessed using in vitro and in vivo models) by targeting the S-phase kinase-associated protein 2(SKP2) gene, which is a component of the SCF (Skp1-Cullin 1-F-box) E3 ubiquitin-ligase complex. The gene discussed is SKP2; the disease is hepatocellular carcinoma.