SKP2 and cancer: Previous studies have shown that overexpression of the SKP2 gene was observed in many cancers, such as in liver cancer (18), prostate cancer (19), lymphoma (20), melanoma (21), and breast cancer (22), which plays an important role in regulating cellular proliferation and cancer progression, mainly by targeting cell cycle regulators in an ubiquitin-dependent manner, followed by 26S proteasome degradation (23).