Although both Skp2 and Psme3 genes were validated as target gene by luciferase reporter assay, our experimental data with Skp2 and Psme3 siRNA showed that only the hepatoma cell transfected with the Skp2 siRNA produced similar phenotype to that of sja-miR-7-5p mimics-treated cells. This evidence concerns the gene SKP2 and hepatocellular carcinoma.