CHEK2 and breast carcinoma: The study from our group (3), summarizing the characteristics of germline mutations in breast cancer susceptibility genes in Chinese women with high-risk breast cancer, found that BRCA1/2 mutations accounted for the majority of hereditary breast cancer, while other genes such as TP53, BRIP1, PALB2, CHEK2, RAD50, NBS1, and RAD51C were only responsible for a smaller fraction (3).