In 2012, Thompson et al. (5) identified the first FANCC deleterious mutations in breast cancer families, with the frequency of FANCC mutations of 0.7% (3/453) in their cohort of BRCA1/2-negative familial breast cancer patients, indicating that FANCC germline mutations in high-risk breast cancer patients would be very rare. The gene discussed is BRCA1; the disease is breast cancer.