E2F4 and neoplasm: Reimer et al. (14, 15) found that the expression level of E2F4 was lower in tissues of platinum-resistant OC patients than in tissues of platinum-sensitive patients, which indicated a tumor suppressor function and prognostic value for E2F4. In our study, the expression of E2F4 was slightly lower in OC tissues than in normal ones and was markedly and negatively correlated with tumor stage in patients with OC.