MICA and cancer: GBM cancer cells also express several MHC-like stress-induced self-antigens (MIC-A/B), heat shock protein-60, U16-binding protein 4, human MutS homolog 2, and F1-ATP synthase, which are recognized by TCRs, Toll-like receptors, or natural killer (NK) receptors expressed on Vγ9Vδ2 T cells, triggering cancer cell killing without any prior antigen exposure or priming (15, 24–26).