CXCR4 and neoplasm: The circulating Vγ9Vδ2 T cells preferentially express inflammatory homing chemokine receptors including CC chemokine receptor (CCR)1, CCR5, CCR8, CXCR3, and C-X-C chemokine receptor type 4 (CXCR4), which are involved in cell migration from the bloodstream to the tumor site, where they display broad and potent antitumoral activity (61–64).