CXCR4 and tuberculosis: Another data-driven immunometabolic subnetwork was centered around a correlation between cortisol and immune signaling genes such as FKBP-5, CXCR4, CEBPD, DDIT4, and SOCS1. This small subnetwork exhibits strong potential for predicting TB with an AUC of 0.77 (0.71–0.82) (Figures 2C,D).