Additionally, many ER chaperones can be detected in the serum, and some of them have been shown to act as autoantigens themselves, with autoantibodies against BiP (32), HSP47 (33), calreticulin (34), calnexin (35), and GRP94 (34, 35) documented in autoimmune diseases. The gene discussed is HSP90B1; the disease is autoimmune disease.