In our experiments a preclinical proof-of-principle study has shown promising results of a combined therapy consisting of ex vivo TKD/IL-2-stimulated NK cells and anti-PD-1 antibody with respect to local tumor control, OS and immune stimulation in immunocompetent and immunodeficient mice with membrane Hsp70-positive tumors (GL261 glioblastoma, A549 lung cancer). Here, IL2 is linked to glioblastoma.