meanwhile, Gal-3 might play a relevant role in HF pathogenic characterization and diagnosis, such as in the prognostic evaluation of worse clinical events (deaths, hospitalization for decompensed HF events, arrhythmias etc.), parallel to old and well known HF biomarkers as BNP, and new HF biomarkers as ST2 protein (Petretta et al., 2007; Katsanos et al., 2017; Sardu et al., 2018b). Here, LGALS3 is linked to hydrops fetalis.