KCNQ1 and Sinus bradycardia: In addition, the effects of several gain-of-function KCNQ1 mutations (V141M, R231C, and V241F) on sinus bradycardia have recently been explored using human in silico models of the sinus node (SN) (Fabbri et al., 2017; Whittaker et al., 2018).