PROM1 and hepatocellular carcinoma: Different studies support the glycolysis dependence of CSCs in diverse types of cancer, such as in radioresistant nasopharyngeal carcinoma spheres with high expression of stage-specific embryonic antigen (SSEA) -3 and -4 compared to parental cells (Shen et al., 2015), CD133+ human hepatocellular carcinoma cells and mouse models (Song et al., 2015; Chen C.L. et al., 2016), ALDH+ (aldehyde dehydrogenase) non-small lung carcinoma cells and side population (SP) cells from human colon cancer (Liu et al., 2014).