SLC16A1 and neoplasm: The best known example is lactate uptake from hypoxic tumor cells or cancer-associated fibroblasts (CAFs) via monocarboxylate transporter 1 and 2 (MCT1 and MCT2) in a process known as reverse Warburg effect (Kroemer and Pouyssegur, 2008; Sonveaux et al., 2008; Porporato et al., 2011; Rattigan et al., 2012).