Moreover, de novo lipogenesis from glycolytic intermediates or acetate via FASN is critical for in vitro self-renewal (Corominas-Faja et al., 2014; Yasumoto et al., 2016), and tumor relapse and metastatic dissemination after withdrawal of anti-angiogenic treatment (Sounni et al., 2014). Here, FASN is linked to neoplasm.