This has been convincingly shown for ROSlow quiescent CD34+ leukemia CSCs (Lagadinou et al., 2013), lung spheroids and CD133+ PDAC cells (Ye et al., 2011; Sancho et al., 2015), as well as CSCs-enriched spheroids form ovarian, cervical and papillary thyroid carcinoma that displayed a reprogrammed metabolism through TCA cycle (Sato et al., 2016; Caria et al., 2018). The gene discussed is CD34; the disease is leukemia.