Indeed, recent pieces of evidence demonstrate the involvement of oncogenes and pluripotency transcription factors, such as MYC, p53, K-Ras, HIF1α, NANOG, MEIS1, Wnt or OCT4 in the metabolic reprogramming from oxidative-dependent metabolism to a glucose dependence in many types of cancer (reviewed in Gabay et al., 2014; Alptekin et al., 2017; Deshmukh et al., 2018). Here, MYC is linked to cancer.