In fact, lipid desaturation, mainly via the enzyme stearoyl-CoA desaturase (SCD-1), plays essential functions controlling self-renewal and tumorigenicity in different cancer models (Noto et al., 2013, 2017; Lai et al., 2017; Li F. et al., 2017), possibly through the activation of stemness-related pathways, such as Wnt signaling (Lai et al., 2017). Here, SCD is linked to cancer.