SREBF1 and ductal breast carcinoma in situ: In fact, the expression of sterol regulatory element-binding protein 1 (SREBP1), master controller of de novo lipogenesis, is increased in CD24-CD44+ESA+ cells from a ductal carcinoma in situ cell line as well as mammospheres and melanospheres (Pandey et al., 2013; Corominas-Faja et al., 2014; Giampietri et al., 2017).