Interestingly, CD36-neutralizing antibodies against either all known functions of CD36 (FA6.152) or the ones reported to block active FA and lipoprotein uptake (JC63.1) induced lipotoxicity in label-retaining/CD44+ metastasis-initiating cells, thus, inhibiting metastasis initiation and progression in oral squamous cell carcinoma, with no reported toxicity in vivo (Pascual et al., 2016). The gene discussed is CD36; the disease is oral cavity squamous cell carcinoma.