KRAS and familial pancreatic carcinoma: However, even though small molecule inhibitors of KRAS proved to be promising in preclinical studies (Xie et al., 2017; Zeng et al., 2017), targeting KRAS or its downstream pathways showed no effect in overall survival and overall response rate in pancreatic cancer patients (Kindler et al., 2012; Infante et al., 2014; Chung et al., 2017).