PSEN1 and Alzheimer disease: As an example, in the APP/PS1 mouse model of AD a significant FA and AD λ// increase was found in the cingulate cortex and striatum; in addition to FA increases in the thalamus, MD and RD λ⊥ increases in the bilateral neocortex, and FA increases in the left hippocampus (Shu et al., 2013).