One of the most studied animal model of AD is the triple transgenic mouse model of AD (3xTg-AD) harboring presenilin 1 (PS1; M146V), amyloid precursor protein (APP; Swe), and tau(P301L) transgenes that progressively develops the pathology associated with human AD (Oddo et al., 2003). The gene discussed is APP; the disease is Alzheimer disease.