NR3C1 and Anxiety: The hippocampus and amygdala are both densely populated with glucocorticoid receptors (GR), and in adolescents with major depression, increased amygdala-hippocampal volume ratios were associated with increased anxiety-related indicators of allostatic load (Macmillan et al., 2003), perhaps due to stimulation of dendritic arborization and new spine formation on pyramidal cells (Morimoto et al., 1996).