CORT and Anxiety: The aims of this study are to: (1) determine whether there are differences in allostatic states for dealing with chronic stress in a threat-induced paradigm, and (2) test whether greater physical activity [i.e., an active offensive response (AOR)] during chronic anxiety (predator stress) is accompanied by altered LHPA axis (CORT) signaling and increased anaerobic glycolysis (lactate) in the amygdala, as may occur in the brain under conditions of high metabolic demand (Riske et al., 2017) and/or hypoxia (Schurr and Rigor, 1998) consequent to higher physical activity.