Increased levels of NCS-1 mRNA were measured in neurons from SNc of PD patients (Dragicevic et al., 2014) and NCS-1 was shown to co-localize with the D2 type-dopamine receptors in dendrites, spines, and occasionally in axonal buttons of rat and monkey striatal neurons (Kabbani et al., 2002), thus supporting the involvement of NCS-1 in the process of dopaminergic signaling, but also suggesting its possible link with PD. Here, NCS1 is linked to Parkinson disease.