These mice and the Alpk1 loss-of-function mice with inflammatory abnormalities were not tested for blindness or retinal dystrophy.35,36 The etiology of the optic nerve edema, splenomegaly, and headache is unclear in ROSAH syndrome patients. This evidence concerns the gene ALPK1 and retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome.