Our results show that many of the cancers identified in the relatives of TC cases are found to be associated with the spectrum of several known cancer syndromes, such as cancers observed in BAP1 tumour predisposition syndrome, Li-Fraumeni syndrome, Familial Melanoma Syndrome, neurofibromatosis and hereditary retinoblastoma. Here, BAP1 is linked to BAP1-related tumor predisposition syndrome.