MBL2 and brain ischemia: The susceptibility of MBL−/−, MBL-A−/−, and MBL-C−/− mice to brain ischemia was evaluated 48 h after ischemic onset, when the ischemic lesion was fully developed in the transient middle cerebral artery occlusion (tMCAo) model.2 Compared with WT mice, MBL−/− ischemic mice had a 40% reduction (p < 0.001), whereas MBL-A−/− and MBL-C−/− mice had a nonsignificant reduction (19% and 7%, respectively) in composite neurological deficits (Fig. 1a).