Murine MBL isoforms were reported to differ in monosaccharide specificity, quite likely leading to preferential binding and potential accessibility to different microorganisms and altered self-structures.16 In brain ischemia, this effect may result in different abilities to bind the endothelial glycocalyx with postischemic modifications and possibly induce earlier MBL-A deposition than MBL-C deposition. This evidence concerns the gene MBL2 and brain ischemia.