Three subtypes of myeloproliferative neoplasms (MPNs): polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are clonal hematological disorders with overlapping phenotypes characterized by oncogenic Janus kinase (JAK)-signal transducers and activators of transcription (STAT)-mediated signaling, associated chronic inflammation, long clinical course, and long-term disease evolution [2]. The gene discussed is SOAT1; the disease is acquired polycythemia vera.