Similar to qPCR results, a higher percentage of SOX2-positive cells was observed in NF1-LRD-expressing tumor (Fig. 3c, d(i)), while that of Vimentin was lower (Fig. 3c, d(ii)), likely indicating a delayed proneural to mesenchymal transition in the NF1-shRNA transduced cells. The gene discussed is SOX2; the disease is neoplasm.