Also, recurrent somatic mutations have been detected in metal-binding residues within the RNase IIIb domain of DICER1, decreasing the expression of some tumor-suppressive miRNAs, which likely helps to explain the selective pressures that give rise to this specific spectrum of mutations in several cancer types [2], including thyroid cancer [8, 15, 16]. The gene discussed is DICER1; the disease is thyroid gland carcinoma.