Overall, these results show that the 3′UTR of DICER1 contains putative binding sites for the most highly overexpressed miRNAs (miR-21-3p, miR-21-5p, miR-221-3p) and that miR-146-5p directly targets DICER1, mediating the potential oncogenic effects and aggressiveness of thyroid cancer cells in vitro. The gene discussed is DICER1; the disease is thyroid cancer.