With respect to genetic risk factors, there are many studies focus on the polymorphisms in the MICA. Kumar et al. first found a previously unidentified locus in the 5′ flanking region of MICA on 6p21.33 (rs2596542G>A) to be strongly associated with HCV-induced HCC in a GWAS [20]. Here, MICA is linked to hepatocellular carcinoma.