Considering that MICA plays an important role in immune activation and surveillance against infection and tumorigenesis, recent studies have mainly focussed on the association between MICA polymorphism and susceptibility to virus-associated cancers, including human papillomavirus-induced cervical cancer [18,19], HBV- or HCV-induced HCC [20–22], and Epstein–Barr virus-associated nasopharyngeal carcinoma [23,24]. Here, MICA is linked to hepatocellular carcinoma.