Reversible mRNA modifications have been proposed in 2010 by the He laboratory (He, 2010) and the discovery of fat mass and obesity-associated (Fto) and AlkB homolog 5 RNA demethylase (Alkbh5) proteins as m6A demethylases in 2011 has finally shown the dynamic, reversible, and adjustable nature of m6A RNA modifications (Jia et al, 2011). Here, ALKBH5 is linked to obesity due to melanocortin 4 receptor deficiency.