ALKBH5 and obesity disorder: Reversible mRNA modifications have been proposed in 2010 by the He laboratory (He, 2010) and the discovery of fat mass and obesity-associated (Fto) and AlkB homolog 5 RNA demethylase (Alkbh5) proteins as m6A demethylases in 2011 has finally shown the dynamic, reversible, and adjustable nature of m6A RNA modifications (Jia et al, 2011).