HNF1B and Kidney Cyst: HNF1B in the mouse (Gresh et al., 2004; Verdeguer et al., 2010) and BICC1 in mice and Xenopus (Tran et al., 2010) regulate the Pkd2 transcript, and mutations in either gene can lead to kidney cysts in mouse models (Gong et al., 2009; Tran et al., 2010).