Yool and colleagues subsequently tested the blocking potential of additional bumetanide derivatives on AQP1 channel conductance and demonstrated attenuation in cancer cell migration upon administration of AqB007 and AqB011 [74]; however, the blocking actions of these derivatives on AQP1 have yet to be demonstrated by other groups, and therefore, their potential actions on CSF secretion remain unknown. Here, AQP1 is linked to cancer.