Recently, through DNA methylation profiling of histologically defined anaplastic pilocytic astrocytoma, Reinhardt et al defined the entity of anaplastic astrocytoma with piloid features, a category of IDH-wildtype astrocytoma with piloid morphology and frequent MAPK pathway alterations, loss of CDKN2A/B, and loss of ATRX. Here, IDH2 is linked to anaplastic astrocytoma.