CHEK2 and colorectal cancer: We identified 10 medically relevant SNVs with statistically significant allele differences between the NVSB and NFE populations including rs2241883 in FABP1 gene previously associated with polycystic syndrome [21] and toxicity of fenofibrate [22], rs1801274 variant in FCGR2A gene shown to be important for the efficiency of trastuzumab in breast neoplasms [23], the rare rs17879961 variant in CHEK2 gene reliably associated with predisposition to breast and colorectal cancer [24] and showed elevated frequency in NVSB.