Typical AD patterns of rCBF may be helpful and are widely used for the diagnosis of dementia in clinical settings.6, , , , , , , -14 However, not all patients with suspected AD exhibit typical AD patterns because the distribution of rCBF varies widely, even in patients with the same underlying AD pathology due to small infarctions, vascular stenosis, and other degenerative conditions, such as widespread tau pathology. The gene discussed is MAPT; the disease is Alzheimer disease.