The median time to tumor initiation defined as the time between tumor cell inoculation and formation of detectable tumors was 27 days for sh-control cells and 33 days for sh-ALDH1A1 OVCAR3 cells (p = 0.003; Figure 3K), suggesting that this isoform plays a functional role in OC cell tumorigenicity. Here, ALDH1A1 is linked to neoplasm.