We analyzed caspase-1 activation and the IL-1β and IL-18 secretion in lipopolysaccharide (LPS)-primed bone marrow-derived macrophages (BMDMs) stimulated with ccf-DNA from patients with type 2 diabetes and poly(dA:dT), an AIM2 inflammasome activator. The gene discussed is AIM2; the disease is type 2 diabetes mellitus.