Finally, we evaluated the suicide effect of PgP/pHSV-TK with GCV in the rat spinal cord tumor model and observed that the percent tumor area in animals treated with PgP/pHSV-TK and GCV was significantly smaller than that of those receiving PgP/pHSV-TK polyplexes without GCV (Figure 7). The gene discussed is PGP; the disease is spinal cord neoplasm.