In recurrent colorectal cancers, the levels of positive regulators of SERPINB2, such as TNF (Z-score = 5.021, p-value = 0.301), JUNB (Z-score = 1.533, p-value = 0.00515) and ERK (Z-score = 3.763, p-value = 0.171), were also increased (Figure 5E). The gene discussed is TNF; the disease is colorectal cancer.