Previous studies documented changes in hepatic desaturases during NAFLD/NASH development: D5D index was found to be lower in genetically obese rats [7] and also a reduction in D6D was detected in high fat diet mice [8]; by contrast, an increase in the hepatic index of SCD1 activity was found in fatty livers and a significant correlation between of SCD1 levels with the severity of hepatic steatosis was documented [9]. This evidence concerns the gene SCD and metabolic dysfunction-associated steatotic liver disease.