Furthermore, Zhang et al. [20] observed a skeletal muscle restoration in chronic obstructive pulmonary disease due to activation and up-regulation of the PGC-1α/SIRT3 signaling pathway through curcumin supplementation, so PGC-1α and SIRT3 are important for the induction of radical oxygen species-detoxifying enzymes. This evidence concerns the gene PPARGC1A and chronic obstructive pulmonary disease.