LARS1 and neoplasm: Furthermore, some myeloid CLRs recognize endogenous molecules to regulate cell differentiation,4, 15 and have been suggested to play important roles in the development of inflammatory diseases and tumors by recognizing molecules released by dead cells16, 17 or expressed on tumor cells.18 Hence, in this review, we will discuss the roles of myeloid CLRs in the development of diseases of the skin and mucoepithelial tissues as well as in the development of tumors.