Upon fungal infection, DECTIN‐1 recognizes β‐(1, 3)‐glucans on the cell wall and activates SYK through ITAM phosphorylation.8 DECTIN‐2 recognizes α‐mannans, another PAMP of fungi, and also activates SYK by recruiting FcRγ.9 Bacterial components, such as trehalose 6, 6′‐dimycolate (TDM) in mycobacteria, can activate MCL.10 SYK activation induces reactive oxygen species (ROS) production, contributing to the eradication of fungi and bacteria. Here, SYK is linked to fungal infectious disease.