IGHE and Alzheimer disease: Malassezia, a commensal fungus on the skin, is also thought to cause AD by producing a variety of immunogenic proteins that elicit specific IgE immune responses.92, 93 MINCLE, expressed on activated phagocytes, can recognize α‐mannosyl residues on Malassezia, resulting in the activation of Mφs to produce inflammatory cytokines and chemokines.94 Mast cells from AD patients also express MINCLE, and upon exposure to Malassezia, Mincle expression, and IL‐6 secretion are enhanced.95