TNF and psoriasis: Psoriasis is a chronic inflammatory skin disease characterized by thickening and redness of the skin associated with keratinocyte hyperproliferation, skin inflammation with inflammatory cell infiltration in the epidermis and dermis, and (in severe cases) aseptic abscess formation.73 Cytokines such as IL‐23, IL‐17A, and TNF play important roles for the pathogenesis of the disease, and the Abs against these cytokines are effective in treating the disease.74, 75 Innate immune responses play important roles in mouse models.