CLEC7A expression is up‐regulated in inflamed colons of IBD patients,28 and 2 single‐nucleotide polymorphisms in CLEC7A are correlated with medically refractory ulcerative colitis.21 Thus, DECTIN‐1 plays important roles not only in host defense against infection, but also in maintaining intestinal homeostasis under physiological conditions (Fig. 1). The gene discussed is CLEC7A; the disease is infection.