IL33 and asthma: Furthermore, fungal and house dust mite (HDM) proteases and a fungal glycosphingolipid release IL‐33 from epithelial cells and Mφs, respectively.43, 44 IL‐33 directly induces the production of inflammatory mediators from basophils, mast cells, and eosinophils, and also indirectly induces inflammatory signaling by promoting Th2 cytokine production from Th2 cells, ILC2, mast cells, and basophils, mostly resulting in development of steroid‐sensitive asthma,42, 45, 46, 47 although some reports have suggested that this phenomenon is involved in steroid resistant asthma48 (Fig. 2).