In these mice, however, impaired killing activity of nonparenchymal NK cells is suggested to be responsible for the defect of antitumor activity.108 On the other hand, in a pancreatic ductal adenocarcinoma model, MINCLE is up‐regulated in tumor‐infiltrating Mφs; in addition, by recognizing a subunit of cytoplasmic histone deacetylase complex SAP130, MINCLE promotes oncogenesis by enhancing Mφ‐induced immune suppression.109. Here, CLEC4E is linked to pancreatic ductal adenocarcinoma.