MR+ inflammatory dendritic epidermal cells are present in samples of skin from patients with atopic dermatitis (AD) or psoriasis, and use this receptor for receptor–mediated endocytosis of mannans.86 MR is suggested to regulate the development of psoriasiform dermatitis in mannan–injected mice, because MR‐deficient mice develop more severe mannan–induced dermatitis, associated with the reduced production of ROS, which is important for the differentiation of immunosuppressive M2 Mφs.87 On the other hand, MR is expressed in CD163+ dermal Mφs together with DC‐SIGN. This evidence concerns the gene CD209 and Alzheimer disease.