KDM6A has been mechanistically implicated as a tumor suppressor in ALL (Ntziachristos et al., 2014; Van der Meulen et al., 2015), AML (Gozdecka et al., 2018), and lung cancer (Wu et al., 2018), and also plays important developmental roles, especially in the heart (Lee et al., 2012; Welstead et al., 2012) and blood (Beyaz et al., 2017; Thieme et al., 2013). This evidence concerns the gene KDM6A and acute lymphoblastic leukemia.