CRHR2 and Anxiety: CRF‐R1 activation is associated with the initiation and consolidation of the long‐term effects on anxiety‐like behaviours caused by exposure to predator stress,27 whereas CRF‐R2 is more commonly related to modulating the recovery response.53 Although CRF‐R2 mRNA expression was unchanged in the brain nuclei examined, which may be part of a ‘stress coping’ mechanism, the reduced expression of CRF‐R1 in the MeA may underlie a homeostatic mechanism to curtail an enhanced fear response that could be damaging to physiological processes.