CRHR1 and major depressive disorder: CRF is known to down‐regulate CRF‐R1 expression in the prefrontal cortex in response to unpredictable stress.39 Similarly, decreased CRF‐R1 expression has been observed in the frontal cortex of suicide victims suffering from depression,40 potentially caused by chronic elevated levels of CRF in the CSF.41 In the present study, the origin of the potential CRF inputs to the MeA are unknown.