TGFB1 and neoplasm: TGFβ-HSF1 was also found to be a key factor of CAF development and metastasis in TNBC.8 Another setting of TGFβ-regulated metastasis observed in TNBC was found to be driven by serglycin (SRGN) induction stimulated by TGFβ via autocrine and paracrine loops.33 Although the master regulators HSF1 and SRGN were different in these two settings, TGFβ was involved in TNBC metastasis likely through an effect on the tumor microenvironment which was reflected in a TGFβ network in plasma.