It has been reported as candidate tumor suppressor in human osteosarcomas27 and clear cell renal carcinomas.28 MAPRE1 is reported as a plasma biomarker for early-stage colorectal cancer and adenoma.29 CLIC1 is connected to VCAM1 and FN1, an essential component of the extracellular matrix (Supplementary Table S8). Here, FN1 is linked to clear cell renal carcinoma.