TGFB1 and neoplasm: The role of TGFβ in tumor progression is well established at the tissue level.5,22 Our study uncovered a TGFβ plasma protein signature predictive of tumor progression based on interaction network analysis23 using established public resources which contain both known and predicted PPIs as in the case of the STRING database.10 Despite extensive curation efforts, the existing maps are considered incomplete,24 we thus also included manually curated interactions from the literature.