CLIC1 and colorectal cancer: It has been reported as candidate tumor suppressor in human osteosarcomas27 and clear cell renal carcinomas.28 MAPRE1 is reported as a plasma biomarker for early-stage colorectal cancer and adenoma.29 CLIC1 is connected to VCAM1 and FN1, an essential component of the extracellular matrix (Supplementary Table S8).