It plays a critical role in the stability of invadopodia in endothelial and tumor cells and the regulation of cell–extracellular matrix interactions and ability of tumor cells to metastasize to distant organs.30 Additionally, CLIC1 has been proposed as a novel prognostic marker for intraperitoneal metastasis in serous epithelial ovarian cancer.31 Considering the candidates of predictive TNBC progression marker showed higher in metastasis, SERPINA3 was grouped together in addition to CLIC1 and MAPRE1 (Fig. 2b, supplementary Fig S7). Here, CLIC1 is linked to neoplasm.