CLIC1 and neoplasm: We next determined whether the three genes CLIC1, MAPRE1 and SEPINA3 that were concordantly upregulated in human metastatic group and mouse fast-growing tumor group can stratify overall survival of TNBC patients using the dataset of Curtis et al.21 The survival curve based on the mRNA levels of signature genes was significantly prognostic in 210 TNBC patients cohort (log rank p = 0.0141, hazard ratio (HR) = 1.804, 95% confidence interval (CI) = 1.042–3.122) described in Fig. 2c.