FN1 and melanoma: Integrins are cell surface receptors that determine tumor cell mobility and survival in secondary organs.46 For instance, α3β1-integrin expression mediates breast carcinoma cell adhesion to FN on lymph nodes,47 and αvβ3-integrin mediates melanoma cell adhesion to VN in the lymph node.48 Together, these studies indicate that the gain-of-function expression of different integrins may direct metastasis to the same secondary organ.