NDRG4 and neoplasm: After knocking down NDRG4 in MCF-7 cells using two distinct shRNA sequences (named shNDRG4 cells, Fig. 4b, c), we did not perceive significant differences in growth curves in vitro or in the incidence of tumors or tumor growth in orthotopic mouse models (Supplementary Fig. S3), indicating that NDRG4 silencing has no significant effect on tumorigenesis or cell proliferation in vitro and in vivo.