O-GlcNAcylation of the p65 subunit of NF-κB in streptozotocin-induced DR mice has been shown to be responsible for hyperglycemia-induced activation of NF-κB and retinal ganglion cell death [51], further linking the involvement of imbalanced O-GlcNAc modification in the etiology of the microvascular complications in DR. Here, NFKB1 is linked to Hyperglycemia.