Lower levels of IL-10 (an anti-inflammatory cytokine) and OPG (an anti-resorption molecule) are observed in patients with DM. Together with the increased levels of their antagonists (IL-6 and RANKL, respectively), the balance between bone resorption and formation is negatively influenced by the diabetic state, leading to a greater periodontal breakdown. The gene discussed is TNFRSF11B; the disease is diabetes mellitus.