THAP4 and acute lymphoblastic leukemia: Three of these genes were also low survival markers, when upregulated, within the youngest 20% of pediatric ALL patients: THAP4, ZNHIT2, and SF3B2 (Additional file 1: Figure S1) of the 1057 genes upregulated in younger patients, and that were independently high survival markers when upregulated, 77 were indicative of higher survival within the oldest 20% of pediatric ALL patients.