ESR1 and breast carcinoma: In contrast to the patterns in premenopausal non-obese women, premenopausal obese women with ER−/PR− breast cancer or ER+/PR− or ER−/PR+ breast cancer did not have higher WBC counts than their age-matched controls, and the trend for higher WBC counts relative to those in the controls was weakened in those with ER+/PR+ breast cancer (Table 2, Fig. 2a).