LEPR and Other metabolic disease: To define whether suppression of Arg2 correlates with metabolic disease, we compared hepatocyte Arg2 expression in fructose-treated and untreated primary hepatocyte cultures, and in LepR heterozygous (db/+) mice with LepR-deficient (db/db) diabetic mice, and in mice fed with a high-fat, high-sucrose diet (HFHS, 14 weeks).