Another Gram-negative bacterium is Shiga toxin (Stx1 and Stx2) producing Escherichia coli (STEC), colonising in the human gut and causing Hemolytic uremic syndrome (HUS), hemorrhagic colitis, pneumonia, urinary infections, meningitis, and bacteremia, diarrhea23. Here, STX1A is linked to hemolytic-uremic syndrome.