Interestingly, the prognostic significance of the NPTX2-PTEN-NF-κB nexus in glioblastoma has been highlighted in a study of Shukla et al.16, which also suggested that NPTX2 inhibits NF-κB activity by reducing AKT via the p53-PTEN-mediated pathway. Here, AKT1 is linked to glioblastoma.