Relative to the depression group, the miR-301b mimic and miR-301b mimic + PLX3397 groups showed obviously decreased expressions of NPTX2, and the miR-301b mimic group displayed increased expressions of p-NF-κB, TNF-α, IL-Iβ, and COX-2 (p < 0.05). The gene discussed is NPTX2; the disease is major depressive disorder.