Compared to the depression group, the miR-301b inhibitor and SN50 groups displayed obviously reduced p-NF-κB protein expression while the miR-301b mimic group showed opposite trends (p < 0.05), and no significant differences were found in the NC, miR-301b mimic + SN50 and miR-301b mimic + PLX3397 groups (p > 0.05). The gene discussed is NFKB1; the disease is depressive disorder.