UGT1A1 and Hyperbilirubinemia: Overall, analyses suggested an increased risk of hyperbilirubinemia in HIV-positive patients with a UGT1A1*28/*28 genotype as compared with those with a UGT1A1*1/*28 or UGT1A1*1/*1 genotype (OR = 5.91, 95%CI = 3.30–10.58; P<0.00001).