The primary finding of the present study is that HIV-positive patients carrying UGT1A1*28 allele(s) including UGT1A1*1/*28 and UGT1A1*28/*28 are at an increased risk of hyperbilirubinemia than those carrying the UGT1A1*1/*1 allele. Here, UGT1A1 is linked to Hyperbilirubinemia.