Culley et al. [30] confirmed the association of hyperbilirubinemia with the use of an ATV/r-containing regimen in individuals carrying the UGT1A1 polymorphism, highlighting also the fact that carriers of the polymorphism develop total bilirubin levels >5 mg/dl in the majority of cases when on ATV/r. This evidence concerns the gene UGT1A1 and Hyperbilirubinemia.