Moderate heterogeneity was detected across all studies (I2 = 40%, P=0.17); and five analyses combined subgroup also suggested an increased risk of hyperbilirubinemia in HIV-positive patients with UGT1A1*28 allele as compared with those with a wild-type allele (OR = 4.89, 95%CI = 2.94–8.14; P<0.00001). The gene discussed is UGT1A1; the disease is Hyperbilirubinemia.