HMGB1 and familial pancreatic carcinoma: In the present study, HMGB1 expression was significantly associated with tumor size, parametrial infiltration, the depth of cervical stromal invasion, and FIGO stage, while KEGG pathway analysis showed that cell cycle, spliceosome, DNA replication, adherens junction, Fc-γ R-mediated phagocytosis, and pancreatic cancer pathway possessed both significant P-values and higher enrichment scores.