In most cases, extracellular HMGB1 binds to various receptors such as Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE), which appears to be important in cancer progression [16,17], especially in proliferation and migration of tumor cells, and in the process of angiogenesis and regeneration [18]. Here, HMGB1 is linked to neoplasm.