GATA6 and esophageal adenocarcinoma: To further assess the potential role of HNF4A and GATA6 initiating Barrett's esophagus, we examined ATAC-seq signal from normal, Barrett's, and EAC tissue at genomic regions bound by HNF4A alone, GATA6 alone, and regions cobound by GATA6 and HNF4A (Supplemental Fig. S8H).