CLRN3 has been identified as a HNF4A transcriptional target in iPSC-derived hepatocytes (Mallanna et al. 2016), and CLDN18 has been confirmed as a GATA6 target in gastric cancer (Sulahian et al. 2014); therefore, we used these likely targets to test the regulatory potential of HNF4A and GATA6 in OE19 cells. The gene discussed is HNF4A; the disease is gastric cancer.