To further assess the potential role of HNF4A and GATA6 initiating Barrett's esophagus, we examined ATAC-seq signal from normal, Barrett's, and EAC tissue at genomic regions bound by HNF4A alone, GATA6 alone, and regions cobound by GATA6 and HNF4A (Supplemental Fig. S8H). Here, GATA6 is linked to Barrett esophagus.