JAK1 and lung cancer: To further elucidate whether ATM downregulates PD-L1 via JAK1,2/STAT3 pathway, we generated ATM-overexpression A549CisR and H157CisR cells (A549CisR-ATM and H157CisR-ATM) and confirmed that ATM-overexpression increased the expression of PD-L1 expression in lung cancer cells (Fig. 5f).