It has reported that a number of signaling pathways is involved both in chemo-resistance and EMT, including HER2-snail axis, MEK/ERK, Stat3 and AKT [6, 7, 9, 26] In addition, Kim HP [26] et al. showed that EMT signaling confers to acquired resistance to gastric cancer. This evidence concerns the gene MAP2K7 and gastric cancer.