MAPT and Creutzfeldt Jacob disease: When the analysis was restricted to tau-related pathology the relative percentage of subjects showing a focal NF pathology in the medial temporal lobe (MTL) was significantly lower in the CJD subtypes linked to the V2 strain than in the one linked to the M1 strain [MM(V)1 subtype] (M1 vs V2, stage 0 − + vs stage I-II RRR 0.56 (95% CI, 0.33-0.96) p = 0.036) (Table 2, Additional file 3: Table S3).