GH1 and Creutzfeldt Jacob disease: Similarly, the recent observation of an unexpected significant Aβ accumulation in the brain of young people affected by iatrogenic CJD, following dura mater graft or treatment with cadaveric-derived human growth hormone (hGH) [12, 32] raised speculations about the possibility of a cross-seeding between PrPSc and Aβ fostering the formation of Aβ plaques, although the recent demonstration that Aβ deposition is equally high in cadaveric hGH recipients without CJD, suggests that Aβ deposition is triggered by the iatrogenic inoculum independently from the prion pathology [22, 63, 64].