Furthermore, we detected a significantly lower degree (i.e. lower mean Braak stage) of NF pathology in the CJD subtypes VV2 and MV2K (i.e. those linked to the V2 strain) in comparison to typical CJDMM(V)1, despite the comparable Aβ pathology. This evidence concerns the gene NFASC and Creutzfeldt Jacob disease.