Given that the CJD MV2K and VV2 subtypes show, on average, more severe pathological changes, including the formation of dot- or stub-like tau deposits in the MTL in comparison to CJDMM(V)1 [39, 56], it is reasonable to believe that the more severe neurodegeneration and the more widespread formation of prion-related tau deposits, possibly causing the sequestration of tau proteins, might have prevented the formation of NF degeneration or made it less visible in such cases. This evidence concerns the gene MAPT and Creutzfeldt Jacob disease.