MAPT and Creutzfeldt Jacob disease: Similarly, likely as a consequence of the absolute predominance the three above-mentioned CJD subtypes within the CJD population, the analysis of tau pathology revealed a significantly lower prevalence of neurofibrillary tau pathology in CJD cases with PrPSc type 2 than in those with PrPSc type 1 (type 1 vs type 2, stage 0 − + vs stage I-II RRR 0.55 (95% CI, 0.32-0.95) p = 0.033).