GTSE1 was found to be overexpressed in HCC and could serve as a marker for poor prognosis as apart from reducing the sensitivity of HCC cells to 5-FU, it could also promote the malignant biological behavior of HCC by improving its proliferative and metastatic ability and upregulating the expression of EMT makers [22, 23]. The gene discussed is GTSE1; the disease is hepatocellular carcinoma.